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US 5,389,640 AGranted
1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
AssigneeMinnesota Mining and Manufacturing Company
InventorsJohn F. Gerster, Stephen L. Crooks, Kyle J. Lindstrom
Life of this patent
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Abstract
1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermediates for preparing such compounds, pharmaceutical compositions containing such compounds, and pharmacological methods of using such compounds.
Claims15
A compound of the formula:
- ##STR10## wherein R.sub.1 is selected from the group consisting of:
- hydroxyalkyl of one to about six carbon atoms and alkoxyalkyl wherein the alkoxy moiety is of one to about four carbon atoms and the alkyl moiety is of one to about six carbon atoms;
- R.sub.2 and R.sub.3 are independently selected from the group consisting of hydrogen and alkyl of one to about four carbon atoms;
- X is selected from the group consisting of alkoxy of one to about four carbon atoms, alkoxyalkyl wherein the alkoxy moiety is of one to about four carbon atoms and the alkyl moiety is of one to about four carbon atoms, hydroxyalkyl of one to about four carbon atoms, and hydroxy;
- and
- R is selected from the group consisting of hydrogen, straight chain or branched chain alkoxy of one to about four carbon atoms, halogen, and straight chain or branched chain alkyl of one to about four carbon atoms;
- or a pharmaceutically acceptable acid addition salt thereof.
4 more elements
Dependencies are inferred from the claim text.