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US 5,389,622 AGranted
Vitamin D3 analogues
AssigneeThe John Hopkins University
InventorsGary H. Posner, Todd D. Nelson
Life of this patent
Estimating the term…
Abstract
A vitamin D.sub.3 analogue having at least one hydroxyalkyl substituent on the A-ring, preferably the 1-position which is useful in inhibiting cell proliferation.
Claims2
In a method of inhibiting cell proliferation by administration of a vitamin D.sub.3 analogue, the modification which comprises administering a vitamin D.sub.3 analogue of the formula:
- ##STR8## and stereoisomers thereof, wherein R is --R.sup.3 OH where R.sup.3 is one of straight and branched alkyl of 1 to 6 carbons, R.sup.1 is hydrogen, and R.sup.2 represents a substituent completing the D.sub.3 analogue.
In a method of inhibiting cell proliferation by administration of a vitamin D.sub.3 analogue, the modification which comprises administering 1-hydroxymethyl-25-hydroxyvitamin D.sub.3 of the formula:
- ##STR9## or the formula:
- ##STR10##
Dependencies are inferred from the claim text.