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US 5,387,744 AGranted
Avirulent microbes and uses therefor: Salmonella typhi
AssigneeWashington University
InventorsRoy Curtiss, III, Sandra M. Kelly
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AssigneeWashington University
InventorsRoy Curtiss, III, Sandra M. Kelly
Estimating the term…
This invention provides immunogenic compositions for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. typhi. The derivatives having a mutation of the cya and/or crp and/or cdt genes. The invention also provides immunogenic compositions for the immunization of a vertebrate and invertebrate comprising an avirulent derivative of the above type which is capable of expressing a recombinant gene derived from a pathogen of said vertebrate or invertebrate individual to produce an antigen capable of inducing an immune response against said pathogen. Other embodiments of the invention include methods of preparing immunogenic compositions from these strains, and strains useful in the preparation of the immunogenic compositions, as well as methods of stimulating the immune system to respond to an immunogenic antigen of S. typhi by administration of the immunogenic composition.
An immunogenic composition for the immunization of an individual comprising a live avirulent Salmonella having a mutation in a cdt gene said live avirulent Salmonella having the phenotype of failure to colonize deep tissue of Salmonella deposit strain ATCC no. 55113.
A method for stimulating the immune system of an individual to respond to an immunogenic antigen of Salmonella comprising administering to said individual an immunogenic composition comprising a live avirulent Salmonella having a mutation in a cdt gene said live avirulent Salmonella having the phenotype of failure to colonize deep tissue of Salmonella deposit strain ATCC no. 55113.
A method for stimulating the immune system to respond to an immunogenic antigen of a pathogen comprising administering to said individual an immunogenic composition comprising a live avirulent Salmonella having a mutation in a cdt gene said live avirulent Salmonella having the phenotype of failure to colonize deep tissue of Salmonella deposit strain ATCC no. 55113.
A biologically pure live avirulent strain of Salmonella said live avirulent Salmonella having the phenotype of failure to colonize deep tissue of Salmonella deposit strain ATCC no. 55113.
A live biologically pure strain of S. typhi having a mutation in a cdt gene said live avirulent Salmonella having the phenotype of failure to colonize deep tissue of Salmonella deposit strain ATCC no. 55113.
A vaccine for the immunization of an individual comprising:
Dependencies are inferred from the claim text.