Method for treating hypertension with disubstituted granidine compounds
AssigneeState of Oregon, acting by and through the Oregon State Board of Higher Education, acting for and on behalf of the Oregon Health Sciences University and the University of Oregon
InventorsJohn Keana, Eckard Weber
Life of this patent
Estimating the term…
Abstract
N,N-disubstituted-guanidines, e.g., of the formula ##STR1## wherein R and R' are substituted or unsubstituted hydrocarbon groups. Methods are provided for the treatment of psychosis and hypertension by administering an effective amount of an N,N'-disubstituted guanidine which, preferably, has a high affinity for the sigma receptor.
Claims26
A method of treating hypertension which comprises administering to a hypertensive person, in an amount effective to ameliorate the hypertensive state, an N,N'-disubstituted guanidine of the following formula ##STR11## wherein R and R' each is substituted or unsubstituted alkyl of at least 4 carbon atoms, a cycloalkyl group of 3 to 12 carbon atoms or a carbocyclic aryl of at least 6 carbon atoms, wherein at least one of said R or R' is adamantyl.
A method of treating hypertension which comprises administering to a hypertensive person, in an amount effective to ameliorate the hypertensive state, a compound selected from the group consisting of (+)-N-(2-exonorbornyl)-N'-(2-iodophenyl)guanidine;
- (-)-N-(2-exonorbornyl)-N'-(2-iodophenyl)guanidine;
- (+)-N-(2-endonorbornyl)-N'-(2-iodophenyl)guanidine;
- (-)-N-(2-endonorbornyl)-N'-(2-iodophenyl)guanidine;
- (+)-N-(2-endonorbornyl)-N'-(o-tolyl)guanidine;
- (+)-N,N'-di-(endo-2-norbornyl)guanidine;
- (-)-N,N'-di-(endo-2-norbornyl)guanidine;
- (+)-N-(exo-2-isobornyl)-N'-(o-iodophenyl)guanidine;
- (-)-N-(exo-2-isobornyl)-N'-(o-iodophenyl)guanidine;
- (+)-N,N'-di-(exo-2-norbornyl)-guanidine;
- (-)-N,N'-di-(exo-2-norbornyl)guanidine;
- (+)-N-(exo-2-isobornyl)-N'-(o-tolyl)guanidine;
- N,N'-di-(1-tetralinyl)guanidine;
- and (-)-N-(exo-2-isobornyl)-N'-(o-tolyl)guanidine.
A method of treating hypertension which comprises administering to a hypertensive person, in an amount effective to ameliorate the hypertensive state, a compound having the formula:
- ##STR12## wherein X and Y are independently branched or straight chain C.sub.1 -C.sub.12 alkylene or a branched or straight chain C.sub.2 -C.sub.12 unsaturated alkylene or wherein one of X and Y is a single bond;
- R and R' are independently hydrogen, a cycloalkyl group of at least 3 carbon atoms, a carbocyclic aryl group of at least 6 carbon atoms, aralkyl of at least 6 carbon atoms and containing 1-3 separate or fused rings, with at least one of said R or R' being adamantyl, and wherein each of R and R' may be substituted in 1-3 positions.
A method of treating hypertension which comprises administering to a hypertensive person, in an amount effective to ameliorate the hypertensive state, a compound of the formula ##STR13## wherein R and R' are an alkyl group of at least 3 carbon atoms, a cycloalkyl group of at least 3 carbon atoms, a carbocyclic aryl group of at least 6 carbon atoms, alkaryl or aralkyl of at least 6 carbon atoms and containing 1-3 separate of or fused rings, and wherein each of R and R' may be substituted in 1-3 positions, with at least one of said R or R' being adamantyl.
A method of treating hypertension which comprises administering to a hypertensive person, in an amount effective to ameliorate the hypertensive state, N-(1-adamantyl)-N'-(o-tolyl)guanidine.
Dependencies are inferred from the claim text.