Nitrosation of homocysteine as a method for treating homocysteinemia
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsJonathan Stamler, Joseph Loscalzo
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Abstract
Administration of a nitrosating compound, such as nitroglycerin, nitric oxide, S-nitrosothiol, S-nitroso-protein, nitroprusside, sydnonimines, furoxans, nitrosonium salts, and related compounds is used for the treatment or prevention of disease states resulting from hyperhomocysteinemia. The disease states include vascular, ocular, skeletal, neurological, and cytotoxicity disorders. In addition, nitrosating compounds may also be administered for the treatment or prevention of disease states resulting from other sulfur-containing amino acids, such as cysteine.
Claims4
A method for treatment or prevention of hyperhomocysteinemia, comprising
- administering an amount effective to treat or prevent hyperhomocysteinemia of a compound selected from the group consisting of S-nitroso-N-acetylcysteine, S-nitroso-glutathione, S-nitroso-cysteine, S-nitroso-homocysteine and S-nitroso-captopril to an individual who has or is to be prevented from having hyperhomocysteinemia.
Dependencies are inferred from the claim text.