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US 5,385,901 AGranted
Method of treating abnormal concentrations of TNF .alpha.
AssigneeThe Rockefeller University
InventorsGilla Kaplan, Elisabeth P. Sampaio
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AssigneeThe Rockefeller University
InventorsGilla Kaplan, Elisabeth P. Sampaio
Estimating the term…
Compounds of the structure ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl radicals of 1-6 carbon atoms, the phenyl radical, and the benzyl radical; and wherein R' is selected from the group consisting of the phthalimido radical and the succinimido radical and of the structure ##STR2## wherein X is CH.sub.2 or C.dbd.O; R" is H, --CH.sub.2 CH.sub.3, --C.sub.6 H.sub.5, --CH.sub.2 C.sub.6 H.sub.5, --CH.sub.2 CH.dbd.CH.sub.2, or ##STR3## and hydrolysis products of said compounds wherein R" is H and the piperidino ring or both the piperidino and the imido ring are hydrolyzed are useful for the control of abnormal concentrations of TNF .alpha. manifested in septic shock, cachexia and HIV infection without substantially effecting the concentration of other cytokines.
The method of treating the toxic symptoms of high concentrations of TNF.sub..alpha. manifested in septic shock, cachexia, and HIV infection by inhibiting the production of TNF.sub..alpha. which comprises administering to a human susceptible to or exhibiting such symptoms an effective amount of a compound of the formula:
The method of treating the debilitating effects of septic shock caused by high concentrations of TNF.sub..alpha. by inhibiting production of TNF.sub..alpha. which comprises administering to a human susceptible to or exhibiting such effects an effective amount of a compound of the formula:
The method of treating the debilitating effects of cachexia caused by high concentrations of TNF.sub..alpha. by inhibiting production of TNF.sub..alpha. which comprises administering to a human susceptible to or exhibiting such effects an amount of a compound of the formula:
The method of treating the debilitating effects of an HIV infection caused by high concentrations of TNF.sub..alpha. by inhibiting production of TNF.sub..alpha. which comprises administering to a human susceptible to or exhibiting such effects an amount of a compound of the formula:
The method of treating the toxic symptoms of high concentrations of TNF.sub..alpha. manifested in septic shock, cachexia, and HIV infection by inhibiting the production of TNF.sub..alpha. which comprises administering to a human susceptible to or exhibiting such symptoms an effective amount of a compound of the formula:
Dependencies are inferred from the claim text.