Radiolabelled peptide compounds
AssigneeMallinckrodt Medical, Inc.
InventorsLeon R. Lyle, Raghavan Rajagopalan, Karen Deutsch
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Abstract
A diagnostic composition suitable for administration to a warm-blooded animal comprising somatostatin or a molecule capable of interacting with the somatostatin receptor labeled with a radionuclide by means of a chelate ligand capable of administration to an animal to produce reliable visual imaging of tumors or therapeutic effects on tumors.
Claims8
A composition comprising somatostatin or a peptide which retains somatostatin receptor specificity conjugated with a N.sub.3 S ligand having the general structure ##STR10## wherein m is a whole number less than eleven;
- p is either 0 or 1;
- PG.sub.1 is a sulfur protecting group selected from the group consisting of C.sub.1-20 S-acyl, C.sub.1-20 alkyl, C.sub.1-10 alkoxyalkyl, carbamoyl and C.sub.1-10 alkoxycarbonyl and X is a coupling moiety selected from the group consisting of carboxyl, amino, isocyanate, isothiocyanate, imidate, maleimide, chlorocarbonyl, chlorosulfonyl, succinimidyloxycarbonyl, haloacetyl and C.sub.1-10 N-alkoxycarbamoyl.
A composition comprising somatostatin or a somatostatin derivative having somatostatin receptor specificity conjugated with a metal complex having the general structure ##STR11## wherein m is a whole number less than eleven;
- p is either 0 or 1;
- X' is a coupling moiety selected from the group consisting of carboxyl, amino, isocyanate, isothiocyanate, imidate, maleimide, chlorocarbonyl, chlorosulfonyl, succinimidyloxycarbonyl, haloacetyl and C.sub.1-10 N-alkoxycarbamoyl;
- and M is technetium, rhenium, gallium, copper or cobalt.
Dependencies are inferred from the claim text.