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AssigneeThe Brigham and Women's Hospital, Inc.
InventorsJonathan Stamler, Joseph Loscalzo, Adam Slivka, Daniel Simon, Robert Brown, Jeffrey Drazen
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S-nitrosothiols exert a potent relaxant effect, mediated both by guanylate cyclase, and a cGMP-independent mechanism, upon non-vascular smooth muscle. Such types of smooth muscle include airway, gastrointestinal, bladder, uterine and corpus cavernosal. Thus, S-nitrosothiols may be used for the treatment or prevention of disorders associated with relaxation of smooth muscle, such as airway obstruction, and other respiratory disorders, bladder dysfunction, premature labor and impotence. Additionally, S-nitrosothiols may be used to alleviate smooth muscle contraction and spasm, and thus facilitate procedures involving diagnostic instrumentation, such as endoscopy, bronchoscopy, laparoscopy and cystoscopy. S-nitrosothiols also increase the binding affinity between hemoglobin and oxygen, and therefore, may be used to improve hemoglobin-oxygen binding, and oxygen transport to bodily tissues.
A method for relaxing airway smooth muscle in an individual in need thereof, comprising administering an airway smooth muscle relaxing amount of a compound selected from the group consisting of S-nitroso-N-acetylcysteine, S-nitroso-glutathione and S-nitroso-homocysteine to a human in need thereof.
A method for treatment or prevention of respiratory disorders involving airway smooth muscle contraction, comprising administering an amount effective to treat or prevent respiratory disorders involving airway smooth muscle contraction of a compound selected from the group consisting of S-nitroso-N-acetylcysteine, S-nitroso-glutathione and S-nitroso-homocysteine to a human in need thereof.
A method for relaxing gastrointestinal smooth muscle, comprising administering a gastrointestinal smooth muscle relaxing amount of a compound selected from the group consisting of S-nitroso-N-acetylcysteine, S-nitroso-glutathione, and S-nitroso-homocysteine to a human in need thereof.
A method for alleviating contraction or spasm of gastrointestinal smooth muscle associated with endoscopic procedures comprising, administering an amount effective for alleviating contraction or spasm of gastrointestinal smooth muscle associated with endoscopic procedures of a compound selected from the group consisting of S-nitroso-N-acetylcysteine, S-nitroso-glutathione and S-nitroso-homocysteine to a human in need thereof.
A method for relaxing corpus cavernosum smooth muscle, comprising, administering a corpus cavernosum smooth muscle relaxing amount of a compound selected from the group consisting of S-nitroso-N-acetylcysteine, S-nitroso-glutathione and S-nitroso-homocysteine to a human in need thereof.
A method for relaxing bladder smooth muscle, comprising administering a bladder smooth muscle relaxing amount of a compound selected from the group consisting of S-nitroso-N-acetylcysteine, S-nitroso-glutathione and S-nitroso-homocysteine to a human in need thereof.
A method for relaxing uterine smooth muscle, comprising administering a uterine smooth muscle relaxing amount of a compound selected from the group consisting of S-nitroso-N-acetylcysteine, S-nitroso-glutathione and S-nitroso-homocysteine to a human in need thereof.
A method for relaxing non-vascular smooth muscle, comprising:
Dependencies are inferred from the claim text.