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US 5,380,747 AGranted
Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
AssigneeEmory University
InventorsRussell M. Medford, Margaret K. Offermann, R. Wayne Alexander
Life of this patent
Estimating the term…
Abstract
Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.
Claims12
A method for the treatment of cardiovascular disease in humans comprising administering to the human an effective amount of a dithiocarbamate of the formula:
- R.sup.1 SC(S)NR.sup.2 R.sup.3
- wherein R.sup.1 is H, sodium, potassium, or NR.sup.4 R.sup.5 R.sup.6 R.sup.7, wherein R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are independently hydrogen, C.sub.1-6 linear, branched, or cyclic alkyl, hydroxy(c.sub.1-6) alkyl, or aryl, and
- R.sup.2 and R.sup.3 are independently C.sub.1-10 linear, branched or cyclic alkyl;
- --(CHOH).sub.n (CH.sub.2).sub.n OH, wherein n is 0-6;
- --(CH.sub.2).sub.n CO.sub.2 R.sup.1, --(CH.sub.2).sub.n CO.sub.2 R.sup.4 ;
- hydroxy(C.sub.1-6)alkyl--, or R.sup.2 or R.sup.3 together constitute a bridge of the formula --(CH.sub.2).sub.m --, wherein m is 3-6, and wherein R.sup.4 is alkyl, aryl, alkylaryl, or aralkyl.
3 more elements
Dependencies are inferred from the claim text.