US 5,376,655 A · Derivatives of p-guanidinobenzoic acid and pharmaceutical agents containing them as an active ingredient

Abstract

A derivative of p-guanidinobenzoic acid of the general formula (IA): ##STR1## wherein Y represents an oxygen atom or a sulfur atom and (a) when Y is an oxygen atom, (R.sup.1).sub.m is selected from the group consisting of: 5-(4-guanidinobenzoyloxy)-3-methoxymethyl, 3,5-dicarboxy, 3,5-bis(isopropoxycarbonyl), 3,5-bistrifluoromethyl, 3-acetyl, 3,5-bis(N-ethylcarbamoyl), and 3,5-bis(N-propylcarbamoyl); (b) when Y is a sulfur atom, (R.sup.1).sub.m is selected from the group consisting of: 2-methyl, 3-methyl, 4-fluoro, 2-chloro, 3-chloro, 2,5-dichloro 2,6-dichloro, 3,4-dichloro, 2-bromo, 2-methoxycarbonyl, and 4-(N,N-diethylaminosulfonyl); or an acid addition salt of said derivative. A method for the treatment or prevention of diseases induced by abnormal enhancing of degradation of proteins by the action of elastase in mammals subject to or suffering therefrom, including the step of administering an effective amount of a p-guanidinobenzoic acid as described herein, is also disclosed.

A method for the treatment or prevention of diseases induced by abnormal enhancing of degradation of proteins by the action of elastase in mammals subject to or suffering therefrom, which comprises the administration of an effective amount of at least one derivative of p-guanidinobenzoic acid of formula (IB):

##STR38## wherein Y represents an oxygen atom or a sulfur atom and (a) when Y is an oxygen atom, R.sup.2 represents
(i) a hydrogen atom;
(ii) an alkyl group of one to four carbon atoms;
(iii) an alkoxy group of one to four carbon atoms;
(iv) an alkoxymethyl group of two to five carbon atoms;
(v) a group represented by the formula:
COOR.sup.3 wherein R.sup.3 represents a hydrogen atom or an alkyl group of one to four carbon atoms;
(vi) a group represented by the formula:
CH.sub.2 COOR.sup.3 wherein R.sup.3 has the same meaning as described hereinbefore;
(vii) a group represented by the general formula:
CH.dbd.CH--COOR.sup.3 wherein R.sup.3 has the same meaning as described hereinbefore;
(viii) a trifluoromethyl group;
(ix) a group represented by the formula:
COR.sup.4 wherein R.sup.4 represents an alkyl group of one to four carbon atoms, a phenyl group, a guanidinophenyl group, a cyclopentylmethyl group or a cyclohexylmethyl group,;
(x) a group represented by the formula:
OCOR.sup.4 wherein R.sup.4 has the same meaning as described hereinbefore;
(xi) a group represented by the general formula:
CH.sub.2 OCOR.sup.4 wherein R.sup.4 has the same meaning as described hereinbefore;
(xii) a group represented by the general formula:
SO.sub.2 R.sup.4 wherein R.sup.4 has the same meaning as described hereinbefore;
(xiii) a group represented by the general formula:
CONR.sup.5 R.sup.6 wherein R.sup.5 and R.sup.6 independently represent a hydrogen atom, an alkyl group of from one to four carbon atoms, a phenyl group, a benzyl group, a pyridyl group, or R.sup.5, R.sup.6 and a nitrogen atom, to which R.sup.5 and R.sup.6 are linked, together represent a pyrrolidinyl group, a piperidino group or a morpholino group;
(xiv) a group represented by the general formula:
OCONR.sup.5 R.sup.6 wherein R.sup.5 and R.sup.6 have the same meaning as described hereinbefore;
(xv) a group represented by the general formula:
SO.sub.2 NR.sup.5 R.sup.6 wherein R.sup.5 and R.sup.6 have the same meaning as described hereinbefore;
(xvi) a group represented by formula (IC):
##STR39## wherein R.sup.5 and R.sup.6 have the same meaning as described hereinbefore;
(xvii) a group represented by the general formula:
NHSO.sub.2 R.sup.7 wherein R.sup.7 represents an alkyl group of from one to four carbon atoms or a phenyl group;
(xviii) a nitro group;
(xix) a hydroxy group;
(xx) a hydroxymethyl group;
(xxi) a guanidino group;
(xxii) a benzyloxy group;
(xxiii) a guanidinophenylthiomethyl group;
(xxiv) a morpholinosulfonylphenoxymethyl group;
(xxv) a pyridyloxymethyl group;
or
(xxvi) (1,1-dioxothiazol-3-yl)carbonyl group;
or
(b) when Y is a sulfur atom, R=hu 2 represents
(i) a hydrogen atom;
(ii) an alkyl group of one to four carbon atoms;
(iii) an alkoxyl group of one to four carbon atoms;
(iv) a halogen atom;
(v) a group represented by the formula:
COOR.sup.3 wherein R.sup.3 has the same meaning as described hereinbefore;
(vi) a group represented by the formula:
CH.sub.2 COOR.sup.3 wherein R.sup.3 has the same meaning as described hereinbefore;
(vii) a nitro group;
or
(viii) a group represented by the formula:
SO.sub.2 NR.sup.5 R.sup.6 wherein R.sup.5 and R.sup.6 have the same meaning as described hereinbefore,
and n represents an integer of one to five, and when n represents two or more, each of the groups represented by R.sup.2 may be the same group or a different group,
or an acid addition salt of the derivative.

53 more elements

Derivatives of p-guanidinobenzoic acid and pharmaceutical agents containing them as an active ingredient

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Derivatives of p-guanidinobenzoic acid and pharmaceutical agents containing them as an active ingredient

Life of this patent

Abstract

Claims2