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US 5,374,662 AGranted
Fumarate and fumaramide siloxane hydrogel compositions
AssigneeBausch & Lomb Incorporated
InventorsYu-Chin Lai, Ronald E. Bambury
Life of this patent
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Abstract
Novel fumarate- and fumaramide-containing monomers are disclosed which are especially useful in the preparation of biocompatible devices, especially contact lenses.
Claims26
A monomer mix comprising
- a) at least one fumaramide-containing monomer having the following schematic representation:
- ##STR10## wherein G is ##STR11## Y.sub.1 and Y.sub.2 are independently O or NR.sub.4 ;
- Z.sub.1 and Z.sub.2 are independently OR.sub.3 or NR.sub.4 R.sub.5 ;
- R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently H or an alkyl group having 1 to 10 C atoms;
- R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 are independently hydrogen, or an alkyl-containing group having 1 to 10 C atoms, or a fluoroalkyl-containing group having 1 to 10 C atoms;
- R.sub.12, R.sub.13 and R.sub.14 are independently methyl, trimethylsiloxy or pentylmethyldisiloxanyloxy;
- m is 1 to 10;
- n is 5 to 100;
- b) at least one hydrophilic monomer;
- and
- c) at least one initiator.
8 more elements
A polymerization product produced from a monomer mix compromising:
- a) at least one fumaramide-containing monomer having the following schematic representations:
- ##STR13## wherein G is ##STR14## Y.sub.1 and Y.sub.2 are independently O or NR.sub.4 Z.sub.1 and Z.sub.2 are independently OR.sub.3 or NR.sub.4 R.sub.5 ;
- R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently H or and alkyl group having 1 to 10 carbon atoms;
- R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 are independently hydrogen, or an alkyl-containing group having 1 to 10 carbon atoms, or a fluoroalkyl-containing group having 1 to 10 carbon atoms;
- R.sub.12, R.sub.13 and R.sub.14 are independently methyl, trimethylsiloxy or pentylmethyldisiloxanyloxy;
- m is 1 to 10;
- n is 5 to 100;
- and
- b) at least one hydrophilic monomer.
6 more elements
A method for preparing a polymerizable material comprising the steps of a) placing into a monomer mix at least one fumaramide-containing monomer having the following schematic representations:
- ##STR15## wherein G is ##STR16## Y.sub.1 and Y.sub.2 are independently O or NR.sub.4 ;
- Z.sub.1 and Z.sub.2 are independently OR.sub.3 or NR.sub.4 R.sub.5 ;
- R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently H or an alkyl group having 1 to 10 C atoms;
- R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 are independently hydrogen, or an alkyl-containing group having 1 to 10 C atoms, or a fluoroalkyl-containing group having 1 to 10 C atoms;
- R.sub.12, R.sub.13 and R.sub.14 are independently methyl, trimethylsiloxy or pentylmethyldisiloxanyloxy;
- m is 1 to 10;
- n is 5 to 100;
- with at least one hydrophilic monomer, and b) curing the monomer mix of step a).
5 more elements
Dependencies are inferred from the claim text.