Use of oxidized polyamines, especially NN'-bis-(3-propionaldehyde)-1-4-diaminobutane (spermine dialdehye) in graft treatment
AssigneeOrtho Phamaceutical Corporation
InventorCatherine Y. Lau
Life of this patent
Estimating the term…
Abstract
Described herein is the use of a substantially pure form of an oxidized polyamine, and especially spermine dialdehyde, in the treatment of tissue grafts or other organs for transplantation. The compounds and treatment are especially useful in treating grafts for bone marrow transplants, whether they be allogeneic or autograft transplants.
Claims41
A method for the selective suppression of at least one subpopulation of deleterious cells within a graft population of mammalian cells which comprises administering to said graft population of mammalian cells, in substantially pure form, a therapeutically effective amount of a compound having the formula:
- ##STR13## to a mammal in need of such selective suppression for a period of time suitable to suppress phenomena deleterious to successful graft transplantation, without substantial suppression of other cells capable of facilitating engraftment.
Dependencies are inferred from the claim text.