Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
AssigneeGenentech, Inc.
InventorIngrid W. Caras
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Abstract
Novel fusions of a GPI signal domain and a polypeptide heterologous to the GPI signal domain donor polypeptide are provided for industrial use. Therapeutic administration of the GPI-linked product of the fusions enables the targeting of biological activity to cell membrane surfaces.
Claims18
A method for preparing a liposome for targeting to a cell of interest, comprising incorporating into the liposome membrane a polypeptide comprising a glycophosphatidylinositol (GPI) anchor fused to a polypeptide heterologous to the GPI anchor that targets the cell of interest.
A composition comprising a liposome, membrane wherein a polypeptide comprising a glycophosphatidylinositol (GPI) anchor fused to a polypeptide heterologous to the GPI anchor is incorporated into the liposome.
Dependencies are inferred from the claim text.