Rotavirus nucleocapsid protein VP6 in vaccine compositions
AssigneeUniversity of Saskatchewan
InventorsMarta I. Sabara, Patrick J. Frenchick, Kerry F. Mullin-Ready
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Abstract
Immunological carrier complexes are provided utilizing the VP6 polypeptide from rotavirus as the carrier molecule. Also provided are methods of binding epitope-bearing molecules (e.g., haptens) to the VP6 carrier molecule through binding peptides. The VP6 carrier can be a VP6 monomer, oligomer, or a particle.
Claims16
An immunological carrier complex that raises an immunological response in a mammal to an epitope,
- said complex comprising:
- a molecule containing an epitope-bearing moiety, coupled to a carrier protein comprising the amino acid sequence of a rotavirus VP6 inner capsid protein.
In an immunological carrier complex including an epitope-bearing moiety coupled to a carrier, the improvement comprising using a protein comprising the amino acid sequence of rotavirus VP6 inner capsid protein as said carrier.
A method of forming an immunological carrier complex including an epitope-bearing moiety comprising:
- (a) providing a carrier protein comprising a rotavirus VP6 inner capsid protein amino acid sequence;
- (b) providing an epitope-bearing moiety contained in a molecule which includes a peptide portion capable of binding said carrier protein through protein-protein interaction;
- and
- (c) contacting said carrier protein with said molecule under conditions whereby said molecule becomes bound to said carrier protein through protein-protein interaction.
Dependencies are inferred from the claim text.