3,5-Substituted benzoylguanidines, process for their preparation, their use as a medicament of diagnostic and medicament containing them

A benzoylguanidine of the formula I

• in which:
• R(1) is R(4)--SO.sub.m or R(5)R(6)N--S0.sub.2 --, where
• m is zero, 1 or 2,
• R(4) and R(5) are C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.6 -alkenyl or --C.sub.n H.sub.2n --R(7),
• n is zero, 1, 2, 3 or 4,
• R(7) is C.sub.5 -C.sub.7 -cycloalkyl or phenyl which is unsubstituted or substituted by 1-3 substituents from the group comprising
• F, Cl, CF.sub.3, methyl, methoxy and NR(8)R(9) where R(8) and R(9) are H or C.sub.1 -C.sub.4 -alkyl,
• where R(5) also has the meaning of H, R(6) is H or C.sub.1 -C.sub.4 -alkyl,
• where R(5) and R(6) together can be 4 or 5methylene groups, of which one CH.sub.2 group can be replaced by O, S, NH, N--CH.sub.3 or N-benzyl,
• R(2) is hydrogen, F, Cl, Br, (C.sub.1 -C.sub.4)-alkyl, O-(CH.sub.2).sub.m C.sub.p F.sub.2p+1 or --X--R(10), where
• m is zero or 1,
• p is 1, 2 or 3,
• x is O, S, or NR(11),
• R(10) is H, C.sub.1 -C.sub.6 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, cyclohexylmethyl, cyclopentylmethyl, or --C.sub.n H.sub.2n --R(12) where
• n is zero, 1, 2, 3 or 4 and
• R(12) is phenyl which is unsubstituted or substituted by 1-3 substituents from the group comprising
• F, Cl, CF.sub.3, methyl, methoxy and NR(8)R(9) where R(8) and R(9) are H or C.sub.1 -C.sub.4 -alkyl,
• R(11) is hydrogen or C.sub.1 -C.sub.3 -alkyl,
• where R(10) and R(11) can also together be 4 or 5 methylene groups and a CH.sub.2 group can be replaced by O, S, NH, N--CH.sub.3 or N-benzyl,
• R(3) is defined as R(1), or is C.sub.1 -C.sub.6 -alkyl, nitro, cyano, trifluoromethyl, F, Cl, Br, I or --X--R(10) where
• X is O, S or NR(11)
• R(10) is H, C.sub.1 -C.sub.6 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, cyclohexylmethyl, cyclopentylmethyl or --C.sub.n H.sub.2n --R(12) where
• n is from zero to 4 and
• R(12) is phenyl which is unsubstituted or substituted by 1-3 substituents from the group comprising
• F, Cl, CF.sub.3, methyl, methoxy and NR(8)R(9) where R(8) and R(9) are H or C.sub.1 -C.sub.4 -alkyl,
• R(11) is H or C.sub.1 -C.sub.3 -alkyl,
• where R(10) and R(11) can also together be 4 or 5 methylene groups and a CH.sub.2 group can be replaced by O, S, NH, N--CH.sub.3 or N-benzyl,
• and their pharmaceutically tolerable salts,
• but where compounds are excluded in which, at the same time:
• R(1) is R(4)--SO.sub.m where m=zero to 2 or R(5)R(6) NSO.sub.2 --,
• R(2) is halogen, (C.sub.1 -C.sub.4)-alkyl, and
• R(3) is --NR(10)R(11).