Method for protection against reactive oxygen species
AssigneeGenentech, Inc.
InventorGrace H. W. Wong
Life of this patent
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Abstract
Methods suitable for the protection inhibtion and prevention of the deleterious effects of reactive oxygen species are provided, wherein an effective amount of a protective agent(s) selected from the group of tumor necrosis factor-alpha and -beta, growth hormone, IL-1, and D-factor is administered. Treatment of tissues and organs to be transplanted is described. Perfusion solutions and the preparation of perfused, excised tissue are described.
Claims24
A method for prophylaxis and treatment of the deleterious effects of reactive oxygen species, comprising the administration to a patient of a cytoprotective amount of at least one cytoprotective agent selected from the group consisting of (a) D-factor (DF), (b) tumor necrosis factor-.alpha. (TNF-.alpha.) plus GH, and (c) tumor necrosis factor-.alpha. (TNF-.alpha.) plus DF.
A method for the protection of ischemic tissues, comprising the administration to said tissue prior to reperfusion of a cytoprotective amount of at least one cytoprotective agent selected from the group consisting of (a) growth hormone (GH), (b) D-factor (DF), (c) tumor necrosis factor-.alpha. (TNF-.alpha.) plus GH, and (d) tumor necrosis factor-.alpha. (TNF-.alpha.) plus DF.
A method for the prophylaxis or treatment of the deleterious effects of reactive oxygen species on tissue to be removed from a donor and transferred to a patient, comprising the administration to said donor prior to the removal of said tissue of a cytoprotective amount of at least one cytoprotective agent selected from the group consisting of (a) growth hormone (GH), (b) D-factor (DF), (c) tumor necrosis factor-.alpha. (TNF-.alpha.) plus GH, and (d) tumor necrosis factor-.alpha. (TNF-.alpha.) plus DF.
Dependencies are inferred from the claim text.