Use of IL-10 to treat inflammatory bowel disease
AssigneeSchering Corporation
InventorDonna Rennick
Life of this patent
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Abstract
The invention provides in vivo methods and compositions for using IL-10 to treat inflammatory bowel disease in a mammal. The method comprises administering to the mammal an effective amount of IL-10, preferably intravascularly, alone or in combination with other therapeutic reagents.
Claims25
A method of treating an inflammatory bowel disease in a mammal comprising:
- administering to the mammal an effective amount of IL-10.
A method of predicting a mammal's predisposition for development of an inflammatory condition associated with inflammatory bowel disease characterized by suboptimal levels of IL-10 comprising:
- 1) assaying a sample taken from the mammal for an IL-10 level and 2) comparing the IL-10 level in the sample to a known normal value of IL-10.
A pharmaceutical composition for administration to a mammal having an inflammatory bowel disease comprising:
- an effective amount of IL-10 to ameliorate at least one of a symptom or a sign of the inflammatory bowel disease in the mammal;
- and
- a pharmaceutically acceptable additive.
The composition of claim 19 wherein the amount of IL-10 is selected from a range of about 1 microgram to about 100 milligrams per kilogram of body weight of the mammal.
Dependencies are inferred from the claim text.