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AssigneeUniversity of Michigan, The Board of Regents
InventorsRobert J. Levy, Amnon Sintov
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Bioprosthetic materials, either natural or synthetic, are treated with trivalent aluminum or iron cations, or salts, to prevent in vivo calcification. Such bioprosthetic materials include porcine aortic valve leaflets, bovine pericardium, aortic homografts, biocompatible elastomers, and the like which are intended for invasive, or in-dwelling use in a human or animal body. Simple incubation of the natural bioprosthetic materials in an ion-containing solution, such as aqueous AlCl.sub.3 or FeCl.sub.3, prior to implantation has been found to inhibit calcification of the biomaterial over a prolonged period, and to do so without adverse side effects. Incorporation of an aluminum-containing compound into the formulation for polymers, such as polyurethane, has also been found to inhibit calcification with no adverse side effects.
An implant formed of a biocompatible biomaterial which is insoluble in the interior of the body of a host, living being, said biomaterial having incorporated therein an effective amount of trivalent aluminum cations to render said biomaterial resistant to in vivo pathologic calcification.
A material suitable for implantation in the interior of the body of a living being, the material being a biocompatible biomaterial having incorporated therein an effective amount of trivalent aluminum cations to render the biomaterial resistant to pathologic calcification in an in vivo environment.
A material for implanting in the interior of a human or animal living body, the material being prepared by the process of:
A method of making a calcification-resistant synthetic polymeric material suitable for implanting in the interior of a human or animal living body, the method comprising the steps of:
A method of making a calcification-resistant biomaterial comprising the step of subjecting bioprosthetic tissue to a solution containing a soluble salt of trivalent aluminum ranging from 0.1 M to 0.001 M for a period of time sufficient to complex aluminum cations in the solution with the bioprosthetic tissue.
A method of making a calcification-resistant synthetic polymeric biomaterial suitable for implanting in the interior of a human or animal living body, the method comprising the steps of:
Dependencies are inferred from the claim text.