Progesterone receptor having C. terminal hormone binding domain truncations
OwnerElisabetta Vegeto, Donald P. McDonnell +1inventors
InventorsElisabetta Vegeto, Donald P. McDonnell, Bert W. O'Malley
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Abstract
The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors.
Claims17
A mutated progesterone receptor protein, wherein said receptor protein is capable of distinguishing a hormone antagonist from an agonist, wherein said protein is mutated by deletion of about 42 to about 54 carboxyl terminal amino acids.
Dependencies are inferred from the claim text.