Ionized magnesium.sup.2+ concentrations in biological samples
AssigneeThe Research Foundation of State University of New York
InventorsBella T. Altura, Burton M. Altura
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Abstract
The present invention provides a method for preparing and storing biological samples prior to measuring ionized Mg.sup.2+ concentrations in order to obtain accurate and reproducible readings. A novel method for accurately reading ionized magnesium ion concentrations in biological samples is provided. A method for monitoring ionized Mg.sup.2+ concentrations and ionized Ca.sup.2+ :Mg.sup.2+ ratios in a patient, useful in diagnosing and prognosing disease states including cardiopulmonary bypass surgery, hypertension, abnormal pregnancy, head trauma, and fetal abnormalities is provided as well as a composition and a method of treating a patient with ionized Mg.sup.2+ or ionized Ca.sup.2+ and Mg.sup.2+.
Claims11
A composition for prevention or treatment of magnesium deficiencies or magnesium imbalances in an individual, the composition comprising as an active ingredient bioavailable magnesium salt, wherein a concentration of bioavailable magnesium salt in said composition is an amount sufficient to maintain normal concentrations of ionized magnesium in a range of approximately 0.53 to 0.67 mM for the biological sample of whole blood, serum or plasma in the individual.
A composition for prevention or treatment of magnesium deficiencies or imbalances or calcium deficiencies or imbalances, or calcium/magnesium imbalances in an individual, the composition comprising as the active ingredients thereof,
- (A) bioavailable calcium salt;
- (B) bioavailable magnesium salt;
- and
- (C) wherein a concentration of the bioavailable calcium salt and the bioavailable magnesium salt in said composition is that amount sufficient to provide a normal molar ratio of ionized Ca.sup.2+ :ionized Mg.sup.2+ in an individual wherein the normal molar ratio of ionized Ca.sup.2+ :ionized Mg.sup.2+ is selected from the group consisting of about 1:1 to about 2.5:1 in whole blood, plasma or serum of an adult, about 1.9:1 to about 2.6:1 in whole blood, plasma or serum of a neonate, infant or child and about 0.90:1 to about 1.15:1 in cerebral spinal fluid.
A composition for prevention or treatment of magnesium deficiencies or magnesium imbalances in an individual, the composition comprising as an active ingredient bioavailable magnesium salt, wherein a concentration of bioavailable magnesium salt in said composition is an amount sufficient to maintain normal concentrations of ionized magnesium in a range of approximately 1.10-1.23 mM for the biological sample of cerebral spinal fluid in the individual.
Dependencies are inferred from the claim text.