Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
AssigneePfizer Inc.
InventorsGeorge Chang, Ernest S. Hamanaka, Peter A. McCarthy, Thien Truong, Frederick J. Walker
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Abstract
Compounds of the formula ##STR1## wherein R.sup.21 and R.sup.22 are as defined in the specification which are intermediates useful in the preparation of compounds of the formula ##STR2## and the pharmaceutically acceptable salts thereof, wherein Q and R.sup.1 are as defined in the specification. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
Claims5
A compound of the formula ##STR10## wherein R.sup.21 is (C.sub.1 -C.sub.3)alkyl and R.sup.22 is hydrogen or (C.sub.1 -C.sub.3)alkyl.
A compound of formula ##STR11## wherein R.sup.21 is (C.sub.1 -C.sub.3)alkyl and R.sup.22 is hydrogen or (C.sub.1 -C.sub.3)alkyl, which contains a tracer amount of radiolabeling.
Dependencies are inferred from the claim text.