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US 5,360,928 AGranted
Synthesis and use of amino acid fluorides as peptide coupling reagents
AssigneeResearch Corporation Technologies, Inc.
InventorsLouis A. Carpino, Dean Sadat-Aalaee
Life of this patent
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Abstract
A compound of the formula ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting group or hydrogen AA is an amino acid residue and X is H or a protecting group useful as a coupling agent in peptide synthesis.
Claims58
A compound of the formula:
- ##STR39## or the acid fluoride salts thereof wherein BLK is an acid labile N-.alpha.-amino protecting group capable of being cleaved by trifluoroacetic acid, a base labile N-.alpha.-amino protecting group, an N-.alpha.-amino acid protecting group removable by hydrogenation, a nucleophile labile N-.alpha.-amino acid protecting group or N-.alpha.-amino protecting group derived from a carboxylic acid;
- AA is an alpha amino acid residue and
- X is - or a protecting group on the side chain of AA.
Dependencies are inferred from the claim text.