1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents

A compound of the formula RCH(OR.sup.1)CH(NR.sup.2 R.sup.3)R.sup.4 or RCH.sub.2 CR.sup.35 (NR.sup.2 R.sup.3)R.sup.4 wherein R is

• wherein R.sup.5 is CH.sub.3 (CH.sub.2).sub.m C.tbd.C--, CH.sub.3 (CH.sub.2).sub.m CH.dbd.CH--, CH.sub.3 (CH.sub.3 (CH.sub.2).sub.m CH.sub.2 CH.sub.2 --, ##STR65## wherein m is 3 to 15, n is 0 to 12, and W and X are independently hydrogen, hydroxy, loweralkyl, loweralkoxy, halogen, or trifluoromethyl, or ##STR66## wherein R.sup.23 is loweralkyl;
• R.sup.1 is hydrogen, loweralkyl, ##STR67## wherein R.sup.24 is loweralkyl or ##STR68## wherein R.sup.6 is hydrogen, loweralkyl, loweralkoxy, N(R.sup.21).sub.2 wherein R.sup.21 is hydrogen, loweralkyl, or ##STR69## wherein W is as above, or ##STR70## R.sup.2 is hydrogen or loweralkyl;
• R.sup.3 is hydrogen, loweralkyl or ##STR71## wherein R.sup.6 is as above or NHR.sup.27 wherein R.sup.27 is loweralkyl;
• R.sup.35 is ##STR72## wherein R.sup.36 is loweralkyl;
• R.sup.4 is ##STR73## wherein R.sup.7 is hydrogen or loweralkyl, C(R.sup.25).sub.2 OR.sup.8 wherein R.sup.8 is hydrogen, loweralkyl, or ##STR74## wherein R.sup.6 is as above and R.sup.25 is hydrogen or loweralkyl;
• R.sup.1 and R.sup.8 taken together with the oxygen to which they are attached form a group of the formula ##STR75## wherein R.sup.9 and R.sup.10 are independently hydrogen or loweralkyl;
• the optical isomers thereof, or the pharmaceutically acceptable salts thereof.