Cyclobutyl oligonucleotide surrogates
AssigneesIsis Pharmaceuticals, Inc., Ciba-Geigy Corporation
InventorsPhillip D. Cook, Gerhard Baschang
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Abstract
Oligonucleotide surrogates comprising a plurality of cyclobutyl moieties covalently joined by linking moieties are prepared and used as antisense diagnostics and research reagents. Methods of synthesis and use of both the oligonucleotide surrogates and intermediates thereof are disclosed.
Claims13
An oligonucleotide surrogate comprising at least two cyclobutyl moieties wherein each of said cyclobutyl moieties include a purine or pyrimidine heterocyclic base attached at a C-1 cyclobutyl position and wherein said cyclobutyl moieties are joined through a C-2, C-3, or C-4 position on a first of said cyclobutyl moieties and a C-2, C-3, or C-4 position on a second of said cyclobutyl moieties by a linkage that contains 4 or 5 consecutive, covalently-bound atoms selected from the group consisting of C, N, O, S, Si and P.
Dependencies are inferred from the claim text.