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US 5,358,649 AGranted
Diagnosis for porcine malignant hyperthermia
AssigneesUniversity of Guelph, The University of Toronto Innovations Foundation
InventorsDavid H. MacLennan, Peter J. O'Brien
Life of this patent
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Abstract
A purified DNA molecule comprises a DNA sequence of approximately 15.1 kb coding for normal or mutant RYR1 protein having a molecular weight of approximately 564,740 daltons. The DNA molecule has an endonuclease restriction map of FIG. 1 and a sequence of FIG. 2.
Claims9
A method for screening a pig to determine if said pig is susceptible to malignant hyperthermia comprising:
- i) providing a biological sample which was removed from said pig to be screened, and
- ii) conducting a biological assay to determine presence in said biological sample of mutant RYR1 gene having a nucleotide mutation of C1843 to T1843 in the DNA sequence of FIG. 2.
Dependencies are inferred from the claim text.