US 5,354,781 A · Benzene derivatives, their preparation and pharmaceutical compositions in which they are present

Abstract

The present invention relates to compounds of the formula ##STR1## in which: p1 R.sub.1 is hydrogen or a halogen atom; R.sub.2 is a cyclohexyl or a phenyl; R.sub.3 is a (C.sub.3 -C.sub.6) cycloalkyl; R.sub.4 is hydrogen, (C.sub.1 -C.sub.6) alkyl or (C.sub.3 -C.sub.6)cycloalkyl; A is --CO--CH.sub.2 --, --CH(CI)--CH.sub.2 --, --CH(OH)--CH.sub.2 --, CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- and --C.tbd.C--, or their addition salt with mineral or organic acids. These compounds are active on the immune system. The present invention further relates to a method of preparing said compounds and to the pharmaceutical compounds in which they are present.

Claims6

Dependent claims

Cis-N-cyclohexyl-N-ethyl-3-(3-chloro-4-cyclohexylphenyl)prop-2-enylamine or one of its pharmaceutically acceptable addition salts.

Dependencies are inferred from the claim text.

Facts

Application

07/707,229Filed 24 May 1991 · continuation

Priority

FR 88 1753830 Dec 1988

Granted

11 Oct 1994

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07C 225/18
And containing six-membered aromatic rings: the carbon skeleton containing also rings other than six-membered aromatic rings
A61P 37/06
Immunomodulators: immunosuppressants, e.g. drugs for graft rejection
C07C 211/35
Of a saturated carbon skeleton: containing only non-condensed rings
C07C 215/38
And containing six-membered aromatic rings: with rings other than six-membered aromatic rings being part of the carbon skeleton

Benzene derivatives, their preparation and pharmaceutical compositions in which they are present

Life of this patent

Benzene derivatives, their preparation and pharmaceutical compositions in which they are present

Life of this patent

Abstract

Claims6