# US 5,352,815 A · Agent for suppression and interception of mailard reaction

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- Number: US 5,352,815 A
- Document ID: US5352815A
- Status: Granted
- Kind: A
- Application number: 08/031,997
- Filed: 1993-03-16
- Granted: 1994-10-04
- Earliest claimed: 1992-03-16
- Assignees: Asai Germanium Research Institute Co., Ltd.
- Inventors: Norihiro Kakimoto; Kunie Nakamura
- Web page: https://patentgrep.com/patent/US5352815A

## CPC

- C07F 7/30: Germanium compounds
- A61K 31/28: Compounds containing heavy metals
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 3/08: for glucose homeostasis (pancreatic hormones A61P5/48)
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides an agent for suppression or interception of the Mailard reaction, which comprises, as the active component, an organogermanium compound represented by formula (1): ##STR1## wherein R.sub.1 to R.sub.3 may be the same or different and each of them represents a hydrogen atom, a lower alkyl group, or a phenyl group; and X represents a hydroxyl group, an O-lower alkyl group, an amino group, or a salt represented by OY (Y is a metal or a basic group-containing compound). Said agent can effectively suppress or intercept the Mailard reaction and has high safety even when administered for a long period of time.

## Claims

### Claim 1

A method for suppressing or intercepting the Mailard reaction, which comprises administering an effective amount of an organogermanium compound represented by formula (1): ##STR8## wherein R.sub.1 to R.sub.3 may be the same or different and each of them represents a hydrogen atom, a lower alkyl group, or a phenyl group; and X represents a hydroxyl group, an O-lower alkyl group, an amino group, or a salt represented by OY, wherein Y is an alkaline metal or a basic group-containing compound.

### Claim 2 (depends on 1)

A method for suppressing or intercepting the Mailard reaction according to claim 1, wherein the organogermanium compound is a compound of formula (1) wherein each of R.sub.1 to R.sub.3 is a hydrogen atom and X is a hydroxyl group.

### Claim 3

A method for suppressing or intercepting the Mailard reaction, which comprises administering an effective amount of an organogermanium compound represented by formula (2): ##STR9## wherein R.sub.1 to R.sub.3 may be the same or different and each of them represents a hydrogen atom, a lower alkyl group, or a phenyl group; and X represents a hydroxyl group, an O-lower alkyl group, an amino group, or a salt represented by OY, wherein Y is an alkaline metal or a basic group-containing compound.

### Claim 4 (depends on 3)

A method according to claim 3 wherein X is a hydroxyl group.

### Claim 5 (depends on 1)

The method according to claim 1 wherein Y is sodium or potassium.

### Claim 6 (depends on 3)

The method according to claim 3 wherein Y is sodium or potassium.

### Claim 7 (depends on 1)

The method according to claim 1 wherein Y is lysozyme or lysine.

### Claim 8 (depends on 3)

The method according to claim 3 wherein Y is lysozyme or lysine.

### Claim 9 (depends on 1)

A method according to claim 1 wherein between about 5 and about 500 mg of the organogermanium compound is administered.

### Claim 10 (depends on 3)

A method according to claim 3 wherein between about 5 and about 500 mg of the organogermanium compound is administered.