# US 5,352,800 A · Process for the production of a novel endothelin antagonist

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- Number: US 5,352,800 A
- Document ID: US5352800A
- Status: Granted
- Kind: A
- Application number: 08/029,745
- Filed: 1993-03-11
- Granted: 1994-10-04
- Earliest claimed: 1993-03-11
- Assignees: Merck & Co., Inc.
- Inventors: Gerard F. Bills; Michael A. Goetz; Robert A. Giacobbe; Lucia Herranz; E. Tracy Turner Jones; Fernando Pelaez; Yu L. Kong; Sheo B. Singh; Siobhan Stevens-Miles
- Web page: https://patentgrep.com/patent/US5352800A

## CPC

- C07D 207/38: 2-Pyrrolones
- Y10S 435/911: using fungi
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

Fermentation processes for the production of a compound of the Structural Formula I ##STR1## The compound of Structural Formula I has been shown to have endothelin antagonist activity and is therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure vasospasm, cerebral and cardia ischemia, myocardial infarction inflammatory diseases, Raynaud's disease, endotoxin shock and asthma.

## Claims

### Claim 1

A compound of structural formula I: ##STR3## or a pharmaceutically acceptable salt selected from the group consisting of the sodium salt, potassium salt, calcium salt, magnesium salt, dicyclohexylamine salt, N-methyl-D-glucamine salt, salt with arginine, salt with lysine, HCl salt, HBr salt, H.sub.2 SO.sub.4 salt, H.sub.3 PO.sub.4 salt, methanesulfonic acid salt, toluenesulfonic acid salt, maleic acid salt, fumaric acid salt camphorsulfonic acid salt.