# US 5,352,799 A · Intermediate compounds useful in the synthesis of kainic acid

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- Number: US 5,352,799 A
- Document ID: US5352799A
- Status: Granted
- Kind: A
- Application number: 08/056,687
- Filed: 1993-04-30
- Granted: 1994-10-04
- Earliest claimed: 1992-12-04
- Assignees: Eli Lilly and Company
- Inventors: James A. Monn
- Web page: https://patentgrep.com/patent/US5352799A

## CPC

- C07D 209/52: condensed with a ring other than six-membered
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The present invention provides processes for the synthesis of kainic acid. More specifically, the present invention is directed to a process for preparing a compound of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl, alkoxycarbonyl, or arylalkoxycarbonyl; R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, aryl, or arylalkyl; and R.sub.3 is hydrogen, C.sub.1 -C.sub.6 alkyl, aryl, or arylalkyl. The present invention also provides processes for the preparation of intermediates that are useful for the synthesis of kainic acid. More specifically, the present invention provides processes for preparing a compound of the formula ##STR2## wherein R.sub.4 is hydrogen, acyl , alkoxycarbonyl, or arylalkoxycarbonyl; and R.sub.5 is hydrogen, C.sub.1 -C.sub.6 alkyl, or arylalkyl.

## Claims

### Claim 1

A compound of the formula ##STR17## wherein R.sub.4 is hydrogen, acyl, alkoxycarbonyl, or arylalkoxycarbonyl; and
R.sub.5 is hydrogen, C.sub.1 -C.sub.6 alkyl, aryl, or arylalkyl.

### Claim 2 (depends on 1)

The compound of claim 1 wherein R.sub.4 is alkoxycarbonyl or arylalkoxycarbonyl, and R.sub.5 is C.sub.1 -C.sub.6 alkyl, aryl, or arylalkyl.

### Claim 3 (depends on 2)

The compound of claim 2 wherein R.sub.4 is arylalkoxycarbonyl and R.sub.5 is C.sub.1 -C.sub.6 alkyl.

### Claim 4 (depends on 3)

The compound of claim 3 wherein R.sub.4 is benzyloxycarbonyl and R.sub.5 is ethyl.

### Claim 5 (depends on 1)

The compound of claim 1 wherein R.sub.4 is hydrogen and R.sub.5 is hydrogen.