# US 5,352,783 A · Microbial transformation product having immunosuppressive activity

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- Number: US 5,352,783 A
- Document ID: US5352783A
- Status: Granted
- Kind: A
- Application number: 08/074,258
- Filed: 1993-06-09
- Granted: 1994-10-04
- Earliest claimed: 1993-06-09
- Assignees: Merck & Co., Inc.
- Inventors: Ali Shafiee; Byron H. Arison; Shieh-Shung T. Chen; Randall R. Miller; Ralph A. Stearns
- Web page: https://patentgrep.com/patent/US5352783A

## CPC

- C07D 498/18: Bridged systems
- C12P 17/188: {Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms (ergot-alcaloids C12P17/183)}
- C12P 19/445: {The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin}
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}

## Abstract

Microbial transformation of a macrolide immunosuppressant by the microorganism Streptomyces sp., (Merck Culture Collection MA 6960) ATCC No. 55387 yields a compound of the structural formula (I): ##STR1## This compound is an immunosuppressant useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

## Claims

### Claim 1

A compound of formula I: ##STR7## or a pharmaceutically acceptable salt thereof.