# US 5,352,770 A · Porcine derived novel physiologically active peptide

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- Number: US 5,352,770 A
- Document ID: US5352770A
- Status: Granted
- Kind: A
- Application number: 07/778,847
- Filed: 1991-12-20
- Granted: 1994-10-04
- Earliest claimed: 1990-04-20
- Inventors: Hisayuki Matsuo
- Web page: https://patentgrep.com/patent/US5352770A

## CPC

- C07K 14/58: Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Disclosed are a novel physiologically active peptide having the following structural formula and an acid addition salt thereof: ##STR1## (where (1)/(2) and (3)/(4) are respectively bonded directly and each of the cysteine residues (Cys) at positions 6 and 22 forms an intramolecular S--S bond). This novel peptide derives from porcine and since it exhibits natriuretic and hypotensive actions, the peptide is useful as a therapeutic for cardiac edema, nephredema, hepatic edema, hypertension, congestive heart failure, acute and chronic renal insufficiency, etc. Further, exhibiting the capability of suppressing the growth of smooth vascular muscle cells and the cGMP producing activity, the novel peptide is anticipated to have the potential for serving as an effective therapeutic for atherosclerosis.

## Claims

### Claim 1

An isolated novel physiologically active peptide having the following structural formula and an acid addition salt thereof: ##STR4## where (1)/(2) and (3)/(4) are respectively bonded directly and each of the cysteine residues (Cys) at positions 6 and 22 forms an intramolecular S--S bond.