# US 5,352,699 A · Use of retinioc acid to treat vaginal atrophy

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 5,352,699 A
- Document ID: US5352699A
- Status: Granted
- Kind: A
- Application number: 08/150,763
- Filed: 1993-11-12
- Granted: 1994-10-04
- Earliest claimed: 1992-04-30
- Assignees: University of Massachusetts Medical Center
- Inventors: Connie Jackson
- Web page: https://patentgrep.com/patent/US5352699A

## CPC

- A61K 31/20: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K 31/07: Retinol compounds, e.g. vitamin A (retinoic acids A61K31/203)
- A61K 33/30: Zinc; Compounds thereof
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A method for the treatment of vaginal atrophy in a human patient in which retinoic acid is administered topically to the patient's vagina.

## Claims

### Claim 1

A method of treating vaginal atrophy in a human patient comprising topically administering retinoic acid to said patient's vagina, said retinoic acid being administered in a dosage sufficient to ameliorate the symptoms of vaginal atrophy.

### Claim 2 (depends on 1)

The method of claim 1 in which said retinoic acid is trans-retinoic acid.

### Claim 3 (depends on 1)

The method of claim 1 in which said retinoic acid is combined with a pharmaceutically acceptable carrier substance.

### Claim 4 (depends on 1)

The method of claim 1, further comprising the step, prior to administration of retinoic acid, of topically administering zinc oxide cream to the vulva of said patient.