# US 5,352,698 A · Methods of treatment for patients suffering from Riley-Day disease

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- Number: US 5,352,698 A
- Document ID: US5352698A
- Status: Granted
- Kind: A
- Application number: 07/945,665
- Filed: 1992-09-16
- Granted: 1994-10-04
- Earliest claimed: 1991-09-17
- Inventors: Maurizio Santini
- Web page: https://patentgrep.com/patent/US5352698A

## CPC

- A61K 31/221: with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
- A61K 31/14: Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205)
- A61K 31/205: Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A61K 31/22: of acyclic acids, e.g. pravastatin
- A61K 31/27: of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A pharmaceutical product is disclosed which interferes with pathologies of human sensitivity and of the motor system. This product comprises parasympathomimetic drugs, in particular carbachol , methacholine or bethanechol and is useful for treating patients suffering from Riley-Day disease.

## Claims

### Claim 1

A method of treatment of a human subject affected by cutaneous and corneal analgesia, ageusia, anosmia and proprioceptive and vestibular areflexia of the Riley-Day disease which consists of administering supra cutem or i.m. to said human subject a composition containing 0.3-9 mgs of carbachol per dose for supra cutem or 0.25-0.75 mgs or carbachol per dose for i.m. administration.

### Claim 2

A method of treatment of a human subject affected by cutaneous and corneal analgesia, ageusia, anosmia and proprioceptive and vestibular areflexia of the Riley-Day disease which consists of administering supra cutem or i.m. to said human subject a composition containing 0.3-9 mgs of methacholine per dose for supra cutem of 0.25-0.75 mgs. of methacholine per dose for i.m. administration.

### Claim 3

A method of treatment of a human subject affected by cutaneous and corneal analgesia, ageusia, anosmia and proprioceptive and vestibular areflexia of the Riley-Day disease which consists of administering to said human subject a composition containing 0.3-9 mgs of the ethyl ether of beta methylcholine chloride per dose for supra cutem administration.

### Claim 4

A method of treatment of a human subject affected by cutaneous and corneal analgesia, ageusia, anosmia and proprioceptive and vestibular areflexia of the Riley-Day disease which consists of administering supra cutem or i.m. to said human subject a composition containing 0.3-15 mgs of bethanechol per dose for supra cutem of 5-15 mgs of bethanechol per dose for i.m. administration.