# US 5,352,691 A · Effective treatment modality for adult respiratory distress syndrome using L-histidine

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- Number: US 5,352,691 A
- Document ID: US5352691A
- Status: Granted
- Kind: A
- Application number: 08/017,766
- Filed: 1993-02-16
- Granted: 1994-10-04
- Earliest claimed: 1993-02-16
- Inventors: Peter G. Thomas
- Web page: https://patentgrep.com/patent/US5352691A

## CPC

- A61K 31/415: 1,2-Diazoles
- A61K 31/4172: Imidazole-alkanecarboxylic acids, e.g. histidine
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

A treatment modality for infectious diseases and pulmonary conditions that result from the inflammatory responses by tissues to infections by microorganisms, including but not limited to viruses, retroviruses, bacteria, or other microorganisms, or toxins that arise from microorganisms comprises administering an effective amount of histidine to the affected subject to combat the disease or the distress condition resulting therefrom.

## Claims

### Claim 1

A method for treating adult respiratory distress syndrome, comprising the step of:
administering to a patient in need thereof, a therapeutically effective amount of L-histidine.

### Claim 2 (depends on 1)

A method, as recited in claim 1, wherein said step of administering is achieved via a route selected from the group consisting of topical, oral, intranasal, intratracheal, transdermal, suppository, intramuscular injection, intrathecal injection, intraperitoneal injection and intravenous injection.

### Claim 3

A method for treating adult respiratory distress syndrome, comprising the step of:
administering to a patient in need thereof, a therapeutically effective amount of a salt of L-histidine.

### Claim 4 (depends on 3)

A method, as recited in claim 3, wherein said step of administering is achieved via a route selected from the group consisting of topical, oral, intranasal, intratracheal, transdermal, suppository, intramuscular injection, intrathecal injection, intraperitoneal injection and intravenous injection.

### Claim 5 (depends on 3)

A method, as recited in claim 3, wherein said salt of L-histidine is selected from the group consisting of ammonium salts, sodium salts, lithium salts, alkaline earth salts and metal salts.