# US 5,352,681 A · Pharmaceutical enema preparation

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 5,352,681 A
- Document ID: US5352681A
- Status: Granted
- Kind: A
- Application number: 08/157,155
- Filed: 1993-12-07
- Granted: 1994-10-04
- Earliest claimed: 1991-06-07
- Assignees: BYK Nederland BV
- Inventors: Adrianus Wittebrood; Adrianus P. De Jong; Jan Bron
- Web page: https://patentgrep.com/patent/US5352681A

## CPC

- A61K 31/60: Salicylic acid; Derivatives thereof
- A61K 9/0031: {Rectum, anus}
- A61K 47/02: Inorganic compounds
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The light, oxidation and storage stability of aqueous 5-ASA suspensions is increased by incorporating in such suspensions an effective amount of titanium dioxide. The resulting stabilized aqueous suspensions are suitable for enema preparations.

## Claims

### Claim 1

An aqueous 5-aminosalicylic acid enema suspension preparation which comprises enema suspension preparation, which titanium dioxide in addition to customary enema suspension auxiliaries.

### Claim 2 (depends on 1)

A preparation as claimed in claim 1, which contains 0.1 to 3% by weight of titanium dioxide.

### Claim 3 (depends on 1)

The preparation as claimed in claim 1, which contains 5-aminosalicylic acid in an amount of from 0.5 to 10% by weight.

### Claim 4 (depends on 1)

A preparation as claimed in claim 1, wherein in each enema suspension auxiliary is a member selected from the group consisting of a viscosity-enhancing substance, preservative, chelating agent, buffer and anti-oxidant.

### Claim 5

An aqueous suspension comprising 5-amino salicylic acid in combination with a light and oxidation stabilizing amount of titanium dioxide.