# US 5,352,677 A · Cinnamamide derivative

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- Number: US 5,352,677 A
- Document ID: US5352677A
- Status: Granted
- Kind: A
- Application number: 07/914,753
- Filed: 1992-07-15
- Granted: 1994-10-04
- Earliest claimed: 1990-07-05
- Assignees: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
- Inventors: Yoshihide Fuse; Kenji Fujii; Keiji Kameyama; Taizo Kawabe; Toshiaki Miwa; Ikuo Katsumi
- Web page: https://patentgrep.com/patent/US5352677A

## CPC

- A61K 31/495: having six-membered rings with two {or more} nitrogen atoms as the only ring heteroatoms, e.g. piperazine {or tetrazines}(A61K31/48 takes precedence {; with three nitrogen atoms A61K31/53})
- C07C 237/22: having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated (peptides C07K)
- C07D 213/40: Acylated substituent nitrogen atom
- C07D 295/104: with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Cinnamamide derivatives and the salts thereof are provided. An antihyperlipidemic composition is also provided. The composition comprises an active ingredient which is at least one selected from the group consisting of the above-mentioned cinnamamide derivative and the pharmaceutically acceptable salt thereof.

## Claims

### Claim 1

A cinnmamide derivative of formula I or a salt thereof: ##STR113## wherein R.sup.l is selected from the group consisting of
--(CH.sub.2).sub.n 1COR.sup.3,
Wherein R.sup.3 is ##STR114## (R.sup.6 is pyridyl or phenyl, and n.sup.3 is an integer of 0 to 3), or ##STR115## (R.sup.7 is alkyl having 1 to 5 carbon atoms) and n.sup.1 is an integer of 1 to 3; ##STR116## Wherein R.sup.8 is ##STR117## (n.sup.6 is an integer of 1 to 3), and R.sup.9 is --OH, --OR.sup.11 (R.sup.11 is alkyl with 1 to 3 carbon atoms); ##STR118## wherein R.sup.25 is ##STR119## (R.sup.26 is phenyl or pyridyl, n.sup.16 is an integer of 1 to 3), and n.sup.15 is an integer of 0 to 3; and
--(CH.sub.2).sub.n 18R.sup.28,
Wherein R.sup.28 is ##STR120## (R.sup.38 is pyridyl), and n.sup.18 is an integer of 0 to 3; R.sup.2 is selected from the group consisting of hydrogen, alkyl having 1 to 5 carbon atoms , and --(CH.sub.2).sub.n 19--C.sub.6 H.sub.5 (n.sup.19 is an integer of 1 to 3); or
R.sup.1 and R.sup.2 may be linked together with the amide nitrogen to form a ring of ##STR121## which is selected from the group consisting of ##STR122## (R.sup.44 is phenyl or pyridyl, and n.sup.20 is an integer of 0 to 2), ##STR123## R.sup.45 is hydrogen or alkyl having 1 to 3 carbon atoms, R.sup.46 is phenyl or pyridyl, and n.sup.21 is an integer of 0 to 2), and ##STR124## (R.sup.47 is alkyl having 1 to 5carbon atoms).

### Claim 2 (depends on 3)

An antihyperlipidemic composition comprising an active ingredient of a cinnamamide derivative and a pharmaceutically acceptable carrier, wherein said active ingredient is selected from the group consisting of a cinnamamide derivative of claim 3 or a pharmaceutically acceptable salt thereof.