Injectable extended release formulations and methods
OwnerNorman D. Brooks, Gregory F. Needhaminventors
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Abstract
Described is a preferred injectable, extended release formulation which includes a growth hormone or a growth hormone releasing factor in a carrier including a biocompatible hydrophobic vehicle and an amount of polyglycerol ester effective to extend release of the growth hormone or growth hormone releasing factor in an animal. Other preferred embodiments provide methods for making a composition for treating an animal with a growth hormone or growth hormone releasing factor, and methods for administering these substances to an animal.
Claims60
A composition of matter of an injectable extended release formulation comprising a growth hormone-related substance selected from the group consisting of growth hormones and growth hormone releasing factors in a carrier including a biocompatible hydrophobic vehicle and an effective amount of polyglycerol ester to extend release of the substance in an animal.
A method for making a composition for treating an animal with a growth hormone-related substance selected from the group consisting of growth hormones and growth hormone releasing factors, comprising incorporating the growth hormone-related substance in a carrier including polyglycerol ester and a biocompatible hydrophobic vehicle to thereby form an injectable formulation, said polyglycerol ester being included in an amount effective to extend release of the growth hormone-related substance in an animal.
A method for administering a growth hormone-related substance selected from the group consisting of growth hormones and growth hormone releasing factors to an animal, comprising injecting into said animal an injectable, extended release formulation including the growth hormone-related substance in a carrier including a biocompatible hydrophobic vehicle and an amount of polyglycerol ester effective to extend release of the substance in the animal.
Dependencies are inferred from the claim text.