# US 5,352,515 A · Coating for tissue drag reduction > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,352,515 A - Document ID: US5352515A - Status: Granted - Kind: A - Application number: 07/843,053 - Filed: 1992-03-02 - Granted: 1994-10-04 - Earliest claimed: 1992-03-02 - Assignees: American Cyanamid Company - Inventors: Peter K. Jarrett; George Jessup; Louis Rosati; Chris Martin; John W. Maney - Web page: https://patentgrep.com/patent/US5352515A ## CPC - A61L 2/081: Gamma radiation - A61L 2/08: Radiation - A61L 17/145: {Coating} - A61L 29/085: {Macromolecular materials} - A61L 31/10: Macromolecular materials - C08G 63/664: derived from hydroxy carboxylic acids - A61L 2103/15: Laboratory, medical or dentistry appliances, e.g. catheters or sharps - Y10T 428/29: Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof - Y10T 428/2967: Synthetic resin or polymer - Y10T 428/2969: Polyamide, polyimide or polyester - Y10T 428/31786: Of polyester [e.g., alkyd, etc.] - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS - Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION ## Abstract This invention relates to materials medical or veterinary use that possess considerably improved properties with regard to friction. The invention also relates to the production of such materials from existing materials that possess suitable bulk properties, but inappropriate frictional properties. This invention also relates to a hydrophilic coating material that provides improved frictional properties. ## Claims ### Claim 1 An article of manufacture comprising a surgical filamentary device having a bioabsorbable coating, the bioabsorbable coating manufactured from an ABA or AB block copolymer having a B block comprising a poly(alkylene oxide) having a number average molecular weight of about 5,000 to 20,000 and an A block comprising a biodegradable random copolymer of (1) glycolide and (2) .epsilon.-caprolactone, wherein the ABA or AB block polymer has a glass transition temperature at or less than 16.degree. C. ### Claim 2 (depends on 1) The article according to claim 1 wherein the B block is poly(ethylene oxide) or poly(ethylene oxide-co-propylene oxide). ### Claim 3 (depends on 1) The article according to claim 1 wherein the poly(alkylene oxide) comprises up to about 95 weight percent and the ratio of glycolide to .epsilon.-caprolactone components is within a range of about 5 weight percent glycolide and 95 weight percent .epsilon.-caprolactone to about 50 weight percent glycolide and 50 weight percent .epsilon.-caprolactone. ### Claim 4 (depends on 3) The article according to claim 3 wherein said ratio is within a range of about 60 to 90 weight percent .epsilon.-caprolactone. ### Claim 5 (depends on 4) The article according to claim 4 wherein said ratio is within a range of about 80 to 90 weight percent .epsilon.-caprolactone. ### Claim 6 (depends on 5) The article according to claim 5 wherein the .epsilon.-caprolactone component is about 85 weight percent. ### Claim 7 (depends on 2) The article according to claim 2 wherein said poly(alkylene oxide) comprises about 20 to 60 weight percent of the ABA polymer. ### Claim 8 (depends on 7) The article according to claim 7 wherein said polymer(alkylene oxide) comprises about 25 to 45 weight percent. ### Claim 9 (depends on 2) The article according to claim 2 wherein the number average molecular weight of said poly(alkylene oxide) is from about 6,000 to 20,000. ### Claim 10 (depends on 9) The article according to claim 9 wherein the said number average molecular weight of said poly(alkylene oxide) is up to about 14,000. ### Claim 11 (depends on 10) The article according to claim 10 wherein said number average molecular weight of said poly(alkylene oxide) is from about 8,000 to 14,000. ### Claim 12 (depends on 1) The article of claim 1 wherein the surgical filamentary device is a suture or ligature. ### Claim 13 (depends on 12) The article of claim 12 wherein the suture or ligature is manufactured from a biocompatible polymer. ### Claim 14 (depends on 13) The article of claim 13 wherein the biocompatible polymer is selected from the group consisting of nylon, polybutester and polypropylene. ### Claim 15 (depends on 12) The article of claim 12 wherein the suture or ligature is a monofilament. ### Claim 16 (depends on 15) The article of claim 15 wherein said suture or ligature is manufactured from a polybutester. ### Claim 17 (depends on 12) The article of claim 12 wherein the suture or ligature is a multifilament. ### Claim 18 (depends on 17) The article of claim 17 wherein said suture or ligature is manufactured from a nonabsorbable polymer selected from the group consisting of polyester, nylon and silk. ### Claim 19 (depends on 1) The article of claim 1 wherein the surgical filamentary device is a knitted or woven mesh. ### Claim 20 A medical or surgical film having a bioabsorbable coating, the bioabsorbable coating consisting essentially of an ABA or AB block copolymer having a B block comprising a poly(alkylene oxide) having a number average molecular weight of about 5,000 to 20,000 and an A block comprising a biodegradable random copolymer of (1) glycolide and (2) .epsilon.-caprolactone, wherein the ABA or AB block polymer has a glass transition temperature at or less than 16.degree. C. ### Claim 21 (depends on 20) The film according to claim 20 wherein the B block is poly(ethylene oxide) or poly(ethylene oxide-co-propylene oxide). ### Claim 22 (depends on 20) The film according to claim 20 wherein the poly(alkylene oxide) comprises up to about 95 weight percent and the ratio of glycolide to .epsilon.-caprolactone components is within a range of about 5 weight percent glycolide and 95 weight percent .epsilon.-caprolactone to about 50 weight percent glycolide and 50 weight percent .epsilon.-caprolactone. ### Claim 23 (depends on 22) The film according to claim 22 wherein said ratio is within a range of about 60 to 90 weight percent .epsilon.-caprolactone. ### Claim 24 (depends on 23) The film according to claim 23 wherein said ratio is within a range of about 80 to 90 weight percent .epsilon.-caprolactone. ### Claim 25 (depends on 24) The film according to claim 24 wherein the .epsilon.-caprolactone component is about 85 weight percent. ### Claim 26 (depends on 22) The film according to claim 22 wherein said poly(alkylene oxide) comprises about 20 to 60 weight percent of the ABA polymer. ### Claim 27 (depends on 26) The film according to claim 26 wherein said poly(alkylene oxide) comprises about 25 to 40 weight percent. ### Claim 28 (depends on 22) The film according to claim 22 wherein the number average molecular weight of said poly(alkylene oxide) is from about 6,000 to 20,000. ### Claim 29 (depends on 28) The film according to claim 28 wherein the said number average molecular weight of said poly(alkylene oxide) is up to about 14,000. ### Claim 30 (depends on 29) The film according to claim 29 wherein said number average molecular weight of said poly(alkylene oxide) is from about 8,000 to 14,000.