# US 5,352,446 A · Method of treating dental caries with monoclonal antibodies against the antigen I and antigen I/II of streptococcus mutans

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- Number: US 5,352,446 A
- Document ID: US5352446A
- Status: Granted
- Kind: A
- Application number: 07/983,273
- Filed: 1992-11-30
- Granted: 1994-10-04
- Earliest claimed: 1986-03-25
- Assignees: Council of Governors of the United Medical and Dental Schools of Guy's and St. Thomas's Hospitals
- Inventors: Thomas Lehner
- Web page: https://patentgrep.com/patent/US5352446A

## CPC

- C07K 16/1275: Streptococcus (G)
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A method of combatting dental caries in a mammal comprises topical application to a surface of a tooth in the mammals mouth of a monoclonal antibody raised against antigen I or antigen I/II of Streptococcus mutans serotype c.

## Claims

### Claim 1

A method of combatting dental caries in a mammal, which comprises topically applying to a surface of a tooth in the mouth of said mammal the monoclonal antibody produced by the hybridoma deposited in the European Collection of Animal Cell Cultures Under the Deposit No. 86031901.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the monoclonal antibody is painted onto the surface of the tooth.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the monoclonal antibody is applied to the surface of the tooth from a tooth paste, mouthwash, chewing gum, lozenge or gel.

### Claim 4 (depends on 1)

The method according to claim 1, wherein about 10-100micrograms of antibody are applied per tooth on each application.