10-desacetoxytaxol derivatives
AssigneesBristol-Myers Squibb Company, Florida State University
InventorsRobert A. Holton, Shu-Hui Chen, Vittorio Farina
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Abstract
The present invention relates to 10-desacetoxytaxol and derivatives thereof, which are useful as antitumor agents. These compounds have the formula ##STR1## wherein R.sub.2 is hydrogen, hydroxy or a protected hydroxy group; R.sub.3 and R.sub.4 are independently hydrogen, hydroxy, a protected hydroxy group, methyl, --SH, --NH.sub.2, or --NR.sub.8 R.sub.9 ; R.sub.5 is R.sub.10, or --OR.sub.10 ; R.sub.6 and R.sub.7 are independently hydrogen, alkyl, or aryl; R.sub.8 and R.sub.9 are independently hydrogen, alkyl, alkenyl, alkynyl, or aryl; and R.sub.10 is alkoxy, alkyl, alkenyl, alkynl, or aryl.
Claims20
A compound of the formula ##STR17## wherein R.sub.2 is hydroxy or a protected hydroxy group;
- R.sub.3 and R.sub.4 are independently hydrogen, hydroxy, a protected hydroxy group, methyl, --SH, --NH.sub.2, or --NR.sub.8 R.sub.9 ;
- R.sub.5 is R.sub.10, or --OR.sub.10 ;
- R.sub.6 and R.sub.7 are independently hydrogen, alkyl, or aryl;
- R.sub.8 and R.sub.9 are independently hydrogen, alkyl, alkenyl, alkynyl, or aryl;
- and R.sub.10 is alkoxy, alkyl, alkenyl, alkynyl, or aryl.
The compound 10-desacetoxytaxol.
The compound 10-deoxytaxotere.
Dependencies are inferred from the claim text.