# US 5,350,864 A · Aminoalkylcarbamyl derivatives of forskolin as intermediates for the synthesis of useful forskolin derivatives

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- Number: US 5,350,864 A
- Document ID: US5350864A
- Status: Granted
- Kind: A
- Application number: 07/518,719
- Filed: 1990-05-03
- Granted: 1994-09-27
- Earliest claimed: 1990-05-03
- Assignees: The United States of America as represented by the Department of Health and Human Services
- Inventors: Kenneth B. Seamon; Joan Robbins; Antonio Laurenza
- Web page: https://patentgrep.com/patent/US5350864A

## CPC

- G01N 33/566: using specific carrier or receptor proteins as ligand binding reagents {where possible specific carrier or receptor proteins are classified with their target compounds}
- C07D 311/92: Naphthopyrans; Hydrogenated naphthopyrans
- G01N 33/9453: {Cardioregulators, e.g. antihypotensives, antiarrhythmics}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The subject matter of the present invention relates to aminoalkylcarbamates of forskolin and the methods of using these compounds. Specifically, the aminoalkylcarbamates may be utilized in the synthesis of forskolin derivatives. The final derivatives may, in turn, be used in the development of in vivo and in vitro assays designed to study different proteins.

## Claims

### Claim 1

A carbamate derivative of forskolin of the formula: ##STR8## wherein R is CONH(R.sub.1)NH.sub.2 ; R.sub.1 is a hydrocarbon group of the formula
(CH.sub.2).sub.n or CH.sub.2 CH.dbd.CH(CH.sub.2).sub.n ; and
n=1, 2, 4, 5 or 7.

### Claim 2

A 6-carbamate derivative of forskolin of the formula: ##STR9## wherein R is CONH(R.sub.1)NH.sub.2 ; R.sub.1 is a hydrocarbon group of the formula (CH.sub.2).sub.n or
CH.sub.2 CH.dbd.CH(CH.sub.2).sub.n ; and
n=1, 2, 4, 5, or 7.

### Claim 3

A 7carbamate derivative of forskolin of the formula: ##STR10## wherein R is CONH(R.sub.1)NH.sub.2 ; R.sub.1 is a hydrocarbon group of the formula (CH.sub.2).sub.n or
CH.sub.2 CH.dbd.CH(CH.sub.2).sub.n ; and
n=1, 2, 4, 5, or 7.

### Claim 4

A 1-carbamate derivative of forskolin of the formula: ##STR11## wherein R is CONH(R.sub.1)NH.sub.2 ; R.sub.1 is a hydrocarbon group of the formula (CH.sub.2).sub.n or
CH.sub.2 H.dbd.CH(CH.sub.2).sub.n ; and
n=1, 2, 4, 5, or 7.

### Claim 5

A 9-carbamate derivative of forskolin of the formula: ##STR12## wherein R is CONH(R.sub.1)NH.sub.2 ; R.sub.1 is a hydrocarbon group of the general formula
(CH.sub.2).sub.n or CH.sub.2 CH.dbd.CH(CH.sub.2).sub.n ; and
n=1, 2, 4, 5, or 7.