# US 5,350,771 A · Method and treatment for hypertension using combination therapy involving exogenous calcium and calcium channel blockers

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- Number: US 5,350,771 A
- Document ID: US5350771A
- Status: Granted
- Kind: A
- Application number: 07/997,629
- Filed: 1992-12-28
- Granted: 1994-09-27
- Earliest claimed: 1990-01-03
- Assignees: Peter K. T. Pang
- Inventors: Peter K. T. Pang; Richard Z. Lewanczuk; Christine G. Benishin
- Web page: https://patentgrep.com/patent/US5350771A

## CPC

- A61K 31/44: Non condensed pyridines; Hydrogenated derivatives thereof
- A61K 31/275: Nitriles; Isonitriles
- A61K 31/55: having seven-membered rings, e.g. azelastine, pentylenetetrazole
- C07K 14/4702: {Regulators; Modulating activity}
- C07K 16/18: against material from animals or humans
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

Hypertensive mammals may be treated to lower mean blood pressure by administering a calcium channel blocking agent together with one or both of a calcium supplement and Vitamin D. The hypotensive effect of this combination is synergistic and the dose response is more predictable than the administration of any of these agents singly.

## Claims

### Claim 1

A method of treatment of hypertensive mammals comprising the administration to a mammal in need of said treatment of
a) a blood pressure lowering effective amount of a benzeneacetonitrile; and
b) a dietary calcium supplement in an amount which is at least five times, by mole, the amount of said benzeneacetonitrile.

### Claim 2 (depends on 1)

A method of treatment according to claim 1, wherein said benzeneacetonitrile is verapamil.

### Claim 3 (depends on 1)

A method of treatment according to claim 1, wherein said calcium supplement is calcium carbonate.

### Claim 4

A pharmaceutical composition, comprising:
a) a blood pressure lowering effective amount of benzeneacetonitrile; and
b) calcium in an amount which is at least five times, by mole, the amount of said benzeneacetonitrile.

### Claim 5 (depends on 4)

A pharmaceutical composition according to claim 4, wherein the benzeneacetonitrile is verapamil.

### Claim 6 (depends on 4)

A pharmaceutical composition according to claim 4 wherein the calcium compound is calcium carbonate.