# US 5,350,763 A · Unguinol and analogs are animal growth permittants

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- Number: US 5,350,763 A
- Document ID: US5350763A
- Status: Granted
- Kind: A
- Application number: 08/075,253
- Filed: 1993-06-11
- Granted: 1994-09-27
- Earliest claimed: 1993-06-11
- Assignees: Merck & Co., Inc.
- Inventors: Scott D. Feighner; Gino M. Salituro; Jack L. Smith; Nancy N. Tsou
- Web page: https://patentgrep.com/patent/US5350763A

## CPC

- A61K 31/335: having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K 31/365: Lactones
- C07D 321/10: condensed with carbocyclic rings or ring systems
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Unguinol is a well-known metabolite of the fungi Aspergillus unguis and Aspergillus nidulans. Unguinol has been found to be an active growth permittant and promotant in animals, in particular, monogastric animals such as chickens. In addition, the fermentation broth also produced the additional known unguinol derivatives of folipastatin and 2-chloro unguinol as well as the novel 4-methyl derivative. All of these compounds are active animal growth permittants. Compositions containing such unguinol derivatives for use as growth permittants and promotants are also disclosed.

## Claims

### Claim 1

A method for promoting the growth of animals and for increasing the efficiency of feed utilization of such animals which comprises administering to such animals an effective amount of unguinol, or derivatives thereof having the following structures: ##STR3## or mixtures thereof.

### Claim 2 (depends on 1)

The method of claim 1 where the compound is unguinol.

### Claim 3 (depends on 1)

The method of claim 1 where the compound is folipastatin.

### Claim 4 (depends on 1)

The method of claim 1 where the compound is 2-chloro unguinol.

### Claim 5 (depends on 1)

The method of claim 1 where the compound is 4-methyl unguinol.

### Claim 6

A composition for promoting the growth of animals and for increasing the efficiency of feed utilization of such animals which comprise a carrier and an effective amount of unguinol derivative having the following structure: ##STR4##

### Claim 7

A compound having the formula ##STR5## which is 4-methyl unguinol.