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US 5,350,583 AGranted
Cell-penetrable medical material and artificial skin
AssigneeTerumo Kabushiki Kaisha
InventorsKatsutoshi Yoshizato, Jun Konishi, Mikio Koide, Kaori Oyamada, Ken-ichi Ohsaki, Takeo Katakura, Yuichi Mori, Ken Tatebe
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Abstract
Cell-penetrable medical material made of denatured collagen which is prepared by heating, in the presence of water is disclosed, the collagen having cross-linking structure. Artificial skin prepared by using this medical material as a wound-contacting layer (2) is also disclosed.
Claims19
Artificial skin which is suitable for application to the site of a wound comprising:
- a wound-contacting layer;
- and
- a water permeation-controlling area laminated on one side said wound-contacting layer for controlling water permeation;
- said wound-contacting layer being made of denatured collagen obtained by heating cross-linked collagen in the presence of water at a temperature ranging from about 50.degree. to about 125.degree. C. and wherein said denatured collagen lacks antigenicity as the antigenic moiety at the terminus of the collagen molecule has been removed.
1 more element
Artificial skin which is suitable for application to the site of a wound comprising:
- a supporting layer having a top and bottom side;
- a wound contacting layer laminated to said bottom side of said supporting layer;
- and
- a water permeation-controlling layer laminated to said top side of said supporting layer,
- said wound-contacting layer comprising denatured collagen obtained by heating cross-linked collagen in the presence of water at a temperature ranging from about 50.degree. to about 125.degree. C. and wherein said denatured collagen lacks antigenicity as the antigenic moiety at the terminus of the collagen molecule has been removed.
2 more elements
Dependencies are inferred from the claim text.