# US 5,350,563 A · Cold sterilant with extended active life

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 5,350,563 A
- Document ID: US5350563A
- Status: Granted
- Kind: A
- Application number: 08/090,791
- Filed: 1993-07-12
- Granted: 1994-09-27
- Earliest claimed: 1986-02-06
- Assignees: STERIS Inc.
- Inventors: Raymond C. Kralovic; David Z. Levin; Lorraine D. H. Lindeman
- Web page: https://patentgrep.com/patent/US5350563A

## CPC

- A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A01N 25/34: Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
- A01N 31/08: Oxygen or sulfur directly attached to an aromatic ring system
- A01N 37/16: containing the group [IMAGE cpc-sch-A01N-0934.gif]; Thio analogues thereof
- A01N 59/00: Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N 59/14: Boron; Compounds thereof
- A61L 2/16: using chemical substances
- A61L 2/18: Liquid substances
- A61L 2/20: Gaseous substances, e.g. vapours
- A61L 2/24: Apparatus using programmed or automatic operation
- A61L 2/26: Accessories
- A61L 11/00: Methods specially adapted for refuse {(disintegrating medical waste B02C19/0075; disposal of medical waste B09B3/00)}
- A61L 15/44: Medicaments
- B65D 77/225: {Pressure relief-valves incorporated in a container wall, e.g. valves comprising at least one elastic element}
- B65D 81/3216: {Rigid containers disposed one within the other}
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- B65D: CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES

## Abstract

Sodium perborate is mixed with a mixture, preferably a 1:1 mixture, of a rapid acetylating agent, e.g. TAED, and a slow acetylating agent, e.g. acetylsalicylic acid, in water to form a biocidally effective peracetic acid solution. When sodium perborate and TAED alone react in water, peracetic acid is produced quickly but has relatively little stability and a short useful life (curve 10). When sodium perborate and acetylsalicylic acid are mixed in water, the peracetic acid solution takes an extended duration to reach maximum efficacy, but is stable for an extended duration (curve 12). The mixture of rapid and slow acetylating agents quickly produces a stable peracetic acid concentration (curve 14).

## Claims

### Claim 1

A powdered mixture which reacts in water to form peracetic acid in an anti-microbial effective concentration, the powdered mixture comprising:
a perborate;
a mixture of a rapid acetyl donor which produces at least two acetyl groups and a slow acetyl donor which produces only a single acetyl group;
a pH buffer.

### Claim 2 (depends on 1)

The mixture as set forth in claim 1 wherein the rapid acetyl donor includes TAED and the slow acetyl donor includes acetylsalicylic acid.

### Claim 3 (depends on 1)

The mixture as set forth in claim 1 wherein the slow acetyl donor includes acetylsalicylic acid.

### Claim 4 (depends on 3)

The mixture as set forth in claim 3 wherein the rapid acetyl donor is selected from the group consisting of TAED, methyl cellulose encapsulated TAED, tetra acetyl glycouril (TAG), penta acetyl glucose (PAG), and mixtures thereof.

### Claim 5 (depends on 4)

The mixture as set forth in claim 4 wherein the acetylsalicylic acid the rapid acetylating agent are present in a 1:1 ratio.

### Claim 6 (depends on 4)

The mixture as set forth in claim 4 further including:
a powdered anti-corrosive material;
a powdered wetting agent; and
a powdered sequestering agent for moving substances that inhibit reaction of the perborate and acetyl donors, and for preventing precipitation of calcium and magnesium salts from hard water.

### Claim 7 (depends on 6)

The mixture as set forth in claim 6 wherein the anti-corrosive agent is selected from the class consisting of: phosphates, molybdates, chromates, dichromates, tungstates, vanadates, borates, benzotriazoles, tolytriazoles, azoles, benzoates, and combinations thereof.

### Claim 8 (depends on 6)

The mixture as set forth in claim 6 wherein the buffering means buffers the resultant peracetic acid solution to a pH between 7.5 and 8.5.

### Claim 9 (depends on 1)

The mixture as set forth in claim 1 wherein the buffering agent buffers the pH of the resultant peracetic acid solution to a pH below 9.

### Claim 10 (depends on 9)

The mixture as set forth in claim 9 wherein the buffering agent buffers the pH of the resultant peracetic acid solution to a pH between 7.5 and 8.5.

### Claim 11 (depends on 1)

The mixture as set forth in claim 1 wherein after peracetic acid concentration has substantially peaked the buffering agent buffers the pH of the resultant peracetic acid solution to a pH of about 7.5.

### Claim 12 (depends on 11)

The mixture as set forth in claim 11 wherein the buffering agent permits higher pHs as the peracetic acid concentration is building towards the maximum.

### Claim 13

A method of microbial decontamination comprising:
mixing water with a perborate and a rapid acetylating agent which produces at least two acetyl groups and which rapidly causes a short term peracetic acid concentration peak, and with a slow acetylating agent which produces only a single acetyl group and which slowly causes a long term peracetic acid concentration peak, and with a buffer to form a solution with a biocidally effective concentration of peracetic acid;
immersing an item to be microbially decontaminated in the solution.

### Claim 14 (depends on 13)

The method as set forth in claim 13 wherein the rapid acetylating agent includes one of TAED, TAG, and PAG.

### Claim 15 (depends on 14)

The method as set forth in claim 14 wherein the slow acetylating agent includes acetylsalicylic acid.

### Claim 16 (depends on 15)

The method as set forth in claim 15 wherein the rapid and slow acetylating agents are present in a ratio of substantially 1:1.

### Claim 17 (depends on 15)

The method as set forth in claim 15 wherein the resultant solution is buffered to a pH between 7.5 and 8.5.

### Claim 18 (depends on 15)

The method as set forth in claim 15 wherein the pH is buffered to a pH greater than 8 during initial peracetic acid formation and after the peracetic acid concentration has substantially reached a peak, reducing the pH of the solution to about 7.5.

### Claim 19 (depends on 18)

The method as set forth in claim 18 wherein the mixing step further includes mixing corrosion inhibitors, sequestering agents, and a wetting agent into the solution.