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AssigneeThe Governors of the University of Alberta
InventorsMichael G. Ikonomou, Paul Kebarle
Estimating the term…
A novel electrospray interface provides high sensitivity and signal stability for mass spectrometric detection of analytes in solvents with high water content including 100% water. The electrospray capillary tip section is heated close to the boiling point of the solvent. An approximately 20.degree. C. hotter airstream is also used. Its flow is coaxial and codirectional to the electrospray. With this arrangement, the analyte signal sensitivity and stability obtained with neat water is equal to that with neat methanol. The charged state (degree of protonation) of protonated peptides sprayed from neat water and the heated spray is essentially identical to that observed with unheated spray where the solvent was 80% methanol-20% water.
An electrospray interface for use with a mass analyzer requiring an ion source, the mass analyzer having an ionization chamber, the interface comprising:
A method of supplying analyte carried by a liquid solvent stream to a mass analyzer having an ionization chamber, the method comprising the steps of:
A method of supplying analyte carried by a liquid solvent stream to a mass analyzer having an ionization chamber, the electrospray interface including a charged capillary source having opposed ends, and the ionization chamber including an oppositely charged plate having an orifice, the method comprising the steps of:
Dependencies are inferred from the claim text.