# US 5,349,056 A · Modified ciliary neurotrophic factors

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- Number: US 5,349,056 A
- Document ID: US5349056A
- Status: Granted
- Kind: A
- Application number: 07/959,284
- Filed: 1992-10-09
- Granted: 1994-09-20
- Earliest claimed: 1992-10-09
- Assignees: Regeneron Pharmaceuticals, Inc.
- Inventors: Nikos Panayotatos
- Web page: https://patentgrep.com/patent/US5349056A

## CPC

- G01N 33/68: involving proteins, peptides or amino acids {(involving lipoproteins G01N33/92)}
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C07K 14/475: Growth factors; Growth regulators
- Y10S 930/12: Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

Modified ciliary neurotrophic factors and methods for their production and therapeutic use. Also described is a method of screening for novel therapeutic proteins by determining altered electrophoretic binding properties.

## Claims

### Claim 1

Modified human ciliary neurotrophic factor comprising human ciliary neurotrophic factor having the modification Gln63.fwdarw.Arg.

### Claim 2 (depends on 1)

Modified ciliary neurotrophic factor according to claim 1 selected from the group consisting of SEQ ID NO:6, SEQ ID NO:9 SEQ ID NO:11, SEQ ID NO:12, and SEQ ID NO:15.

### Claim 3 (depends on 1, 2)

A composition comprising a substantially pure modified ciliary neurotrophic factor according to claim 1 or 2 and a carrier.