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US 5,349,053 AGranted
Chimeric ligand/immunoglobulin molecules and their uses
AssigneeProtein Design Labs, Inc.
InventorNicholas F. Landolfi
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Abstract
Chimeric molecules having a ligand component linked to an immunoglobulin constant region component are provided for various diagnostic, therapeutic and other uses. These immunoligands can exhibit the high degree of specificity associated with the ligand, yet retain various effector functions characteristic of immunoglobulin heavy chains.
Claims12
A chimeric immunoligand comprising:
- an interleukin-2 ligand component comprising an interleukin-2 amino acid sequence capable of binding an interleukin-2 receptor;
- and
- an immunoglobulin constant region component comprising an immunoglobulin constant region domain without an immunoglobulin variable region domain;
- wherein the ligand component and the constant region component are in peptide linkage, the immunoligand is capable of binding to an interleukin-2 cell surface receptor through the ligand component, and the immunoligand is capable of fixing complement and/or mediating antibody dependent cell cytotoxicity through the constant region component, due to binding of the immunoligand to the cell surface receptor.
1 more element
Dependencies are inferred from the claim text.