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US 5,349,052 AGranted
Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor
AssigneeRoyal Free Hospital School of Medicine
InventorsCristina Delgado, Gillian E. Francis, Derek Fisher
Life of this patent
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Abstract
The invention relates to fractionating a mixture of polyethylene glycol (PEG)-protein adducts having different degrees of PEG substitution by partitioning the PEG-protein adducts in a PEG-containing aqueous biphasic system according to the degree of PEG substitution. A new PEG-gm-CSF obtained by the process is useful in pharmaceutical compositions for use in therapeutic or diagnostic methods.
Claims9
A process for fractionating a mixture of polyethylene glycol (PEG)-protein adducts having different degrees of PEG substitution comprising:
- (a) partitioning the PEG-protein adducts in a PEG-containing aqueous biphasic system according to the degree of PEG substitution, and
- (b) recovering a PEG-protein adduct of predetermined degree of PEG substitution from one phase of the biphasic system.
Dependencies are inferred from the claim text.