# US 5,349,045 A · Polymer derived from cyclic amide and medical devices manufactured therefrom

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- Number: US 5,349,045 A
- Document ID: US5349045A
- Status: Granted
- Kind: A
- Application number: 08/009,122
- Filed: 1993-01-26
- Granted: 1994-09-20
- Earliest claimed: 1993-01-26
- Assignees: United States Surgical Corporation
- Inventors: Ying Jiang
- Web page: https://patentgrep.com/patent/US5349045A

## CPC

- C08G 69/14: Lactams
- A61L 17/10: containing macromolecular materials
- A61L 31/06: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)}
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

A moldable and/or extrudable polymer which is useful for the manufacture of surgical devices such as sutures, staples, clips, etc., possesses structural units derived from a cyclic amide monomer containing oxygen, sulfur or nitrogen in the ring.

## Claims

### Claim 1

A copolymer suitable for fabrication into a useful article by at least one fabrication method selected from the group consisting of molding and extruding, the copolymer possessing structural units derived from a cyclic amide monomer of the general formula: ##STR4## wherein Z is O, S or NR"; each of R, R' and R" individually is the same or different and is hydrogen or methyl; and, x is 1 to 5, y is 1 to 5 and the sum of x and y is at least 3, and structural units derived from at least one other monomer selected from the group consisting of caprolactam, .epsilon.-caprolactone, glycolide, glycolic acid, lactide, lactic acid, p-dioxanone and trimethylene carbonate.

### Claim 2 (depends on 1)

The copolymer of claim 1 wherein the cyclic amide monomer is selected from the consisting of 3-morpholinone, 4-oxavalerolactam, 3-oxacaprolactam, 4-oxacaprolactam and 5-oxacaprolactam.

### Claim 3

A medical device fabricated in whole or in part from a polymer possessing structural units derived from a cyclic amide monomer of the general formula: ##STR5## wherein Z is O, S or NR"; each of R, R' and R" individually is the same or different and is hydrogen or methyl; and, x is 1 to 5, y is 1 to 5 and the sum of x and y is at least 3, and structural units derived from at least one other monomer selected from the group consisting of caprolactam, .epsilon.-caprolactote, glycolide, glycolic acid, lactide, lactic acid, p-dioxanone and trimethylene carbonate.

### Claim 4 (depends on 3)

The medical device of claim 3 wherein the cyclic amide monomer is selected from the group consisting of 3-morpholinone, 4-oxavalerolactam, 3-oxacaprolactam, 4-oxacaprolactam and 5-oxacaprolactam.

### Claim 5 (depends on 3)

The medical device of claim 3 wherein the device is selected from the consisting of clip, staple, suture, mesh, growth matrix, screw, pin and anastomosis ring.

### Claim 6

A linear copolymer suitable for fabrication into a useful article by at least one fabrication method selected from the group consisting of molding and extruding, the copolymer comprising structural units of the formula: ##STR6## wherein Z is O, S or NR"; each of R, R' and R" individuality is the same or different and is hydrogen or methyl; and, x is 1 to 5, y is 1 to 5 and the sum of x and y is at least 3 and structural units derived from at least one other monomer selected from the group consisting of caprolactam, .epsilon.-caprolactone, glycolide, glycolic acid, lactide, lactic acid, p-dioxanone and trimethylene carbonate.